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Hexamethonium Dibromide

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Hexamethonium Dibromide Specification

Usage
Used as a ganglionic blocker in laboratory research

Poisonous
YES

Storage
Store in tightly closed container, dry, and cool place

EINECS No
207-618-1

Taste
Bitter

Solubility
Soluble in water

Purity
>98%

Application
Research, pharmaceutical intermediate

Shelf Life
2 years

Appearance
White crystalline

HS Code
29212990

Ingredients
Hexamethonium Dibromide

Product Type
Pharmaceutical Raw Material

Properties
White to off-white crystalline powder, hygroscopic

Physical Form
Powder

CAS No
484-19-1

Grade
Pharmaceutical Grade

Density
1.2 Gram per cubic centimeter(g/cm3)

Structural Formula
(CH3(CH2)5N(CH3)3)2Br2

Melting Point
285C (decomposes)

Molecular Weight
350.19 g/mol

Smell
Odorless

Shape
Crystals or crystalline powder

Molecular Formula
C12H30Br2N2

EC Number
207-618-1

Handling Precautions
Avoid inhalation, ingestion, and contact with skin and eyes

Stability
Stable under recommended storage conditions

Boiling Point
Not applicable (decomposes)

Packaging
Available in HDPE bottles or customized as required

Usage Area
Laboratory, pharmaceutical manufacturing

Synonyms
Hexamethylenebis(trimethylammonium bromide)

Hazard Class
Toxic if swallowed

Hexamethonium Dibromide Trade Information

Main Export Market(s)
Australia, Central America, North America, South America, Western Europe, Middle East, Asia, Eastern Europe, Africa

Main Domestic Market
All India

About Hexamethonium Dibromide

Hexamethonium Dibromide is a chemical compound that belongs to the class of compounds known as nicotinic antagonists, with the chemical formula C₁₂H₃₀Br₂N₂. It is a white crystalline powder that is soluble in water and ethanol. It is used primarily as a ganglionic blocker in medical research and clinical settings. It is a quaternary ammonium compound composed of six carbon chains attached to a central nitrogen atom with two bromide anions. It acts by blocking the nicotinic acetylcholine receptors in the autonomic ganglia, that leads to a decrease in sympathetic and parasympathetic tone. It is used clinically as an antihypertensive agent and as a preoperative medication.

FAQ

1. What is hexamethonium dibromide?

Ans - The antispasmodic medication hexamethonium dibromide is used to treat cramps and muscular spasms. The treatment of some types of urine incontinence also involves it.

2. How does hexamethonium dibromide function?

Ans - Hexamethonium Dibromide lessens the severity of muscle cramps and spasms by inhibiting nerve signals from the brain to the muscles.

3. What are the Hexamethonium Dibromide side effects?

Ans - Hexamethonium dibromide may cause dry mouth, impaired vision, drowsiness, and an accelerated heart rate.

4. Which individuals should not use hexamethonium dibromide?

Ans - Hexamethonium Dibromide should not be taken by anyone who has glaucoma, an enlarged prostate, cardiac issues, or an overactive thyroid.

5. Is hexamethonium dibromide safe to use over the long term?

Ans - Although hexamethonium dibromide is often safe for long-term usage, it is crucial to see a doctor before using it for an extended period of time.

Research and Pharmaceutical Applications

Hexamethonium Dibromide serves mainly as a ganglionic blocker in laboratory and pharmaceutical intermediate research. Its precise formulation, high purity, and stability make it an essential component for experimental protocols and synthesis processes in the pharmaceutical sector. It is trusted for its consistent performance and reliable chemical properties.

Safe Handling and Storage Guidelines

Due to its toxic nature, Hexamethonium Dibromide must be handled carefully, avoiding inhalation, ingestion, and skin or eye contact. Store the compound in tightly sealed containers placed in a cool, dry area. Proper storage ensures product stability and preserves its quality for up to two years, maximizing its usability in research settings.

FAQ's of Hexamethonium Dibromide:

Q: How should Hexamethonium Dibromide be handled to ensure safety?

A: Always handle Hexamethonium Dibromide in a well-ventilated laboratory, using personal protective equipment like gloves and safety goggles. Avoid inhaling dust, ingesting the compound, or allowing contact with skin and eyes. Promptly clean up any spills and follow your laboratory's safety procedures.

Q: What is the primary usage of Hexamethonium Dibromide in laboratories?

A: Hexamethonium Dibromide is chiefly used as a ganglionic blocker in laboratory and pharmaceutical manufacturing research. Its application extends to studies involving neural transmission and testing the effects of autonomic nervous system inhibitors.

Q: Where should Hexamethonium Dibromide be stored for optimal stability?

A: Store Hexamethonium Dibromide in a tightly closed HDPE bottle or customized container. Keep it in a cool, dry place away from moisture and direct sunlight to preserve its stability and efficacy for up to two years.

Q: When is it necessary to choose customized packaging for Hexamethonium Dibromide?

A: Customized packaging is advisable when specific research or transportation requirements demand particular container sizes, materials, or labeling. This ensures safe storage and handling tailored to unique laboratory or industrial needs.

Q: What precautions must be taken during the disposal process?

A: Dispose of Hexamethonium Dibromide according to local hazardous chemical regulations. Ensure waste is handled by authorized professionals, using sealed containers, to prevent environmental contamination or accidental exposure.

Q: What benefits does Hexamethonium Dibromide offer in pharmaceutical research?

A: Its high purity, consistent stability, solubility in water, and reliable performance as a ganglionic blocker make Hexamethonium Dibromide valuable for experimental procedures, enhancing the quality and reproducibility of research outcomes.

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